1h6f

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spinqualitylabelsall models PDB ID 1h6f Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1h6f, resolution 1.70Å ()
Ligands:
Structural annotation: Resources: CATH : 1H6Fa00, 1H6Fb00 InterPro : Ipr001699, Ipr008967 Pfam : PF00907 SCOP : d1h6fa_, d1h6fb_ UniProt : O15119
Functional annotation: Cellular component: nucleus Biological process: positive regulation of cell proliferation embryonic digit morphogenesis regulation of transcription from RNA polymerase II promoter cell aging negative regulation of myoblast differentiation multicellular organismal development anti-apoptosis follicle-stimulating hormone secretion luteinizing hormone secretion male genitalia development transcription negative regulation of transcription, DNA-dependent regulation of transcription, DNA-dependent skeletal development positive regulation of cell cycle determination of anterior/posterior axis, embryo forelimb morphogenesis female genitalia development embryonic arm morphogenesis organ morphogenesis mammary gland development mesoderm morphogenesis Molecular function: transcription repressor activity DNA binding general transcriptional repressor activity transcription factor activity sequence-specific DNA binding RNA polymerase II transcription factor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 HUMAN TBX3, A TRANSCRIPTION FACTOR RESPONSIBLE FOR ULNAR-MAMMARY SYNDROME , BOUND TO A PALINDROMIC DNA SITE 2 About this Structure 3 See Also 4 Reference

HUMAN TBX3, A TRANSCRIPTION FACTOR RESPONSIBLE FOR ULNAR-MAMMARY SYNDROME , BOUND TO A PALINDROMIC DNA SITE

Template:ABSTRACT PUBMED 12005433

About this Structure

1h6f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• T-box proteins
• TBX3
• User:Helen Ginn

Reference

• Coll M, Seidman JG, Muller CW. Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome. Structure. 2002 Mar;10(3):343-56. PMID:12005433
• Muller CW, Herrmann BG. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor. Nature. 1997 Oct 23;389(6653):884-8. PMID:9349824 doi:10.1038/39929
• Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am J Hum Genet. 2007 Aug;81(2):280-91. Epub 2007 Jun 15. PMID:17668378 doi:S0002-9297(07)61194-X