Allosteric modulation of H-Ras GTPase

From Proteopedia

spinqualitylabelsall models PDB ID 3k8y Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3k8y, resolution 1.30Å ()
Ligands:	, , ,
Gene:	HRAS, HRAS1 (Homo sapiens)
Related:	2rge, 3k9n, 3k9l
Structural annotation: Resources: InterPro : Ipr015592, Ipr020849, Ipr013753, Ipr003577, Ipr005225, Ipr001806 Pfam : PF00071
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

H-Ras is a small monomeric GTPase protein that is found inside of cells. It helps regulate cell division in cells through signal transduction pathways such as the Ras pathway. H-Ras is also known as a molecular switch, it contains two switch regions: Switch I and Switch II. Switch I is a Thymine 35 and switch II is a Glycine 60, both of these switches depend on the phosphate group on a GTP molecule to turn “on” and “off”. In the Ras catalytic cycle, Ras is activated when it attaches to a GTP molecule turning both switch regions “on”. This pathway also involves GTPase activating protein, which hydrolyzes the GTP attached to the Ras causing the switches to turn “off”.