2ht6
From Proteopedia
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Crystal structure of Human Gem G-domain bound to GDP
Contents |
Overview
Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique, sequence features. We report here the crystallographic structure, determination of the Gem G-domain in complex with nucleotide to 2.4 A, resolution. Although the basic Ras protein fold is maintained, the Gem, switch regions emphatically differ from the Ras paradigm. Our ensuing, biochemical characterization indicates that Gem G-domain markedly prefers, GDP over GTP. Two known functions of Gem are distinctly affected by, spatially separated clusters of mutations.
Disease
Known diseases associated with this structure: Long QT syndrome-7 OMIM:[600681], Short QT syndrome-3 OMIM:[600681]
About this Structure
2HT6 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure-function studies of the G-domain from human gem, a novel small G-protein., Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA, FEBS Lett. 2006 Oct 30;580(25):5959-64. Epub 2006 Oct 6. PMID:17052716
Page seeded by OCA on Fri Feb 15 17:33:25 2008
