Phenylethanolamine N-methyltransferase

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Image:3kpj.jpg
Crystal Structure of Phenylethanolamine N-methyltransferase 3kpj

Template:STRUCTURE 3kpj

Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. The images at the left and at the right correspond to one representative PNMT, i.e. the crystal structure of Phenylethanolamine N-methyltransferase (3kpj).

Contents

3D Structures of Phenylethanolamine N-methyltransferase

Update June 2012

3kpj – hPNMT+AdoHcy – human
3kpu, 3kpv, 3kpw, 3kpy, 3kqm, 3kqo, 3kqp, 3kqq, 3kqs, 3kqt, 3kqv, 3kqw, 3kqy, 3kr0, 3kr1, 3kr2, 3hcb, 3hcc, 3hcf, 2ony, 2g70, 2g71, 2g8n, 2an5, 1yz3, 1n7i, 1n7j, 1hnn - hPNMT+AdoHcy+ligand
3hca, 3hce, 2obf, 2onz, 2obp - hPNMT (mutant)+AdoHcy+ligand
3hcd - hPNMT+AdoHcy+noradrenaline
2g72 - hPNMT+AdoMet+ligand
2an3 - hPNMT+AdoHcy+substrate analog
2an4 - hPNMT+AdoHcy+octopamine
4dm3 - hPNMT+AdoHcy + resorcinol + imidazole

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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