3uzy

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Template:STRUCTURE 3uzy

Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and 5beta-dihydrotestosterone

Template:ABSTRACT PUBMED 22437839

About this Structure

3uzy is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Chen M, Drury JE, Christianson DW, Penning TM. Conversion of human steroid 5beta-reductase (AKR1D1) into 3beta-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering. J Biol Chem. 2012 May 11;287(20):16609-22. Epub 2012 Mar 20. PMID:22437839 doi:10.1074/jbc.M111.338780

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Categories: Homo sapiens | Chen, M. | Christianson, D W. | Penning, T M. | Aldo-keto reductase | Catalytic tetrad mutant | Oxidoreductase | Steroid and bile acid metabolism | Tim barrel

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