4a2j

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Image:4a2j.png

Template:STRUCTURE 4a2j

PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids

Template:ABSTRACT PUBMED 22535964

About this Structure

4a2j is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lusher SJ, Raaijmakers HC, Vu-Pham D, Kazemier B, Bosch R, McGuire R, Azevedo R, Hamersma H, Dechering K, Oubrie A, van Duin M, de Vlieg J. X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11beta-Substituted Steroids. J Biol Chem. 2012 Jun 8;287(24):20333-43. Epub 2012 Apr 25. PMID:22535964 doi:10.1074/jbc.M111.308403

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