1a06
From Proteopedia
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CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
Overview
The crystal structure of calcium/calmodulin-dependent protein kinase I has been determined in the autoinhibited form. The C-terminal regulatory region of the enzyme forms a helix-loop-helix segment that extends across the two domains of the catalytic core, making multiple inhibitory interactions. Elements of the first regulatory alpha helix and the loop interfere with the binding site for peptide substrates, while the loop and the second helix interact with the ATP-binding domain to induce conformational changes that obstruct the nucleotide binding pocket. One part of the calmodulin recognition element protrudes away from the catalytic domain and is potentially available for an initial interaction with calmodulin. The structure provides a view of an intact calmodulin target and suggests that substantial structural changes will accompany kinase activation by calmodulin binding to the regulatory region.
About this Structure
1A06 is a Single protein structure of sequence from Rattus norvegicus. Active as Calcium/calmodulin-dependent protein kinase, with EC number 2.7.11.17 Full crystallographic information is available from OCA.
Reference
Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I., Goldberg J, Nairn AC, Kuriyan J, Cell. 1996 Mar 22;84(6):875-87. PMID:8601311
Page seeded by OCA on Thu Feb 21 11:39:27 2008
