3vhc

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Template:STRUCTURE 3vhc

Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor

Template:ABSTRACT PUBMED 22192591

About this Structure

3vhc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Suda A, Koyano H, Hayase T, Hada K, Kawasaki K, Komiyama S, Hasegawa K, Fukami TA, Sato S, Miura T, Ono N, Yamazaki T, Saitoh R, Shimma N, Shiratori Y, Tsukuda T. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1136-41. Epub 2011 Dec 1. PMID:22192591 doi:10.1016/j.bmcl.2011.11.100

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