3um5

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Template:STRUCTURE 3um5

Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP

Template:ABSTRACT PUBMED 22526319

About this Structure

3um5 is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S. Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil. Antimicrob Agents Chemother. 2012 Jul;56(7):3928-35. Epub 2012 Apr 23. PMID:22526319 doi:10.1128/AAC.00301-12

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Categories: Plasmodium falciparum | Chitnumsub, P. | Kamchonwongpaisan, S. | Vanichtanankul, J. | Yuthavong, Y. | Antifolate | Dump | Malarial dhfr-t | Napdh | Oxidoreductase | Pyrimethamine | Transferase-inhibitor complex

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