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3tik

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Revision as of 06:27, 25 July 2012 by OCA (Talk | contribs)
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Image:3tik.png

Template:STRUCTURE 3tik

Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one

Template:ABSTRACT PUBMED 22777048

About this Structure

3tik is a 4 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.

Reference

  • Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH. Pharmacological Characterization, Structural studies, and In Vivo Activity of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib. Antimicrob Agents Chemother. 2012 Jul 9. PMID:22777048 doi:10.1128/AAC.06244-11

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OCA

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