1nr6

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Template:STRUCTURE 1nr6

Contents 1 MICROSOMAL CYTOCHROME P450 2C5/3LVDH COMPLEX WITH DICLOFENAC 2 About this Structure 3 See Also 4 Reference

MICROSOMAL CYTOCHROME P450 2C5/3LVDH COMPLEX WITH DICLOFENAC

Template:ABSTRACT PUBMED 12899620

About this Structure

1nr6 is a 1 chain structure of Cytochrome P450 with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

See Also

• Cytochrome P450

Reference

• Wester MR, Johnson EF, Marques-Soares C, Dijols S, Dansette PM, Mansuy D, Stout CD. Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding. Biochemistry. 2003 Aug 12;42(31):9335-45. PMID:12899620 doi:http://dx.doi.org/10.1021/bi034556l
• He XY, Shen J, Hu WY, Ding X, Lu AY, Hong JY. Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. Arch Biochem Biophys. 2004 Jul 15;427(2):143-53. PMID:15196988 doi:10.1016/j.abb.2004.03.016
• Murthy JN, Nagaraju M, Sastry GM, Rao AR, Sastry GN. Active site acidic residues and structural analysis of modelled human aromatase: a potential drug target for breast cancer. J Comput Aided Mol Des. 2005 Dec;19(12):857-70. Epub 2006 Apr 22. PMID:16741831 doi:10.1007/s10822-005-9024-0