1t4e

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Image:1t4e.png

Template:STRUCTURE 1t4e

Contents

Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor

Template:ABSTRACT PUBMED 15715460

About this Structure

1t4e is a 2 chain structure of MDM2 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Petrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem. 2005 Feb 24;48(4):909-12. PMID:15715460 doi:10.1021/jm049137g

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