1pah

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Template:STRUCTURE 1pah

Contents 1 HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424 2 About this Structure 3 See Also 4 Reference

HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424

Template:ABSTRACT PUBMED 9406548

About this Structure

1pah is a 1 chain structure of Phenylalanine hydroxylase with sequence from Homo sapiens. The January 2005 RCSB PDB Molecule of the Month feature on Phenylalanine Hydroxylase by Shuchismita Dutta and David S. Goodsell is 10.2210/rcsb_pdb/mom_2005_1. Full crystallographic information is available from OCA.

See Also

• Phenylalanine hydroxylase

Reference

• Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC. Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria. Nat Struct Biol. 1997 Dec;4(12):995-1000. PMID:9406548
• Bjorgo E, Knappskog PM, Martinez A, Stevens RC, Flatmark T. Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria. Eur J Biochem. 1998 Oct 1;257(1):1-10. PMID:9799096
• Andersen OA, Flatmark T, Hough E. Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation. J Mol Biol. 2002 Jul 26;320(5):1095-108. PMID:12126628
• Sandelin E. On hydrophobicity and conformational specificity in proteins. Biophys J. 2004 Jan;86(1 Pt 1):23-30. PMID:14695246 doi:10.1016/S0006-3495(04)74080-1