1w22

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Template:STRUCTURE 1w22

Contents 1 CRYSTAL STRUCTURE OF INHIBITED HUMAN HDAC8 2 About this Structure 3 See Also 4 Reference

CRYSTAL STRUCTURE OF INHIBITED HUMAN HDAC8

Template:ABSTRACT PUBMED 15477595

About this Structure

1w22 is a 2 chain structure of Histone deacetylase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Histone deacetylase

Reference

• Vannini A, Volpari C, Filocamo G, Casavola EC, Brunetti M, Renzoni D, Chakravarty P, Paolini C, De Francesco R, Gallinari P, Steinkuhler C, Di Marco S. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15064-9. Epub 2004 Oct 11. PMID:15477595
• Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 2008 Dec 23;47(51):13554-63. PMID:19053282 doi:10.1021/bi801610c