1z62

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Template:STRUCTURE 1z62

Contents 1 Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites 2 About this Structure 3 See Also 4 Reference

Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites

Template:ABSTRACT PUBMED 15153119

About this Structure

1z62 is a 1 chain structure of Glycogen Phosphorylase with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

See Also

• Glycogen Phosphorylase

Reference

• Kosmopoulou MN, Leonidas DD, Chrysina ED, Bischler N, Eisenbrand G, Sakarellos CE, Pauptit R, Oikonomakos NG. Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex. Eur J Biochem. 2004 Jun;271(11):2280-90. PMID:15153119 doi:10.1111/j.1432-1033.2004.04173.x
• Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure. 1997 Nov 15;5(11):1413-25. PMID:9384557