3klh

Categories: Human immunodeficiency virus 1 | Mus musculus | Arnold, E. | Sarafianos, S G. | Tu, X. | Aid | Azt | Azt excision | Azt resistance | Azt resistance mutation | Dna polymerase | Dna-directed dna polymerase | Hiv | Hiv-1 | Magnesium | Metal-binding | Multifunctional enzyme | Nrti | Nuclease | Nucleoside inhibitor | Nucleotide excision | P51/p66 | Resistance mechanism | Reverse transcriptase | Rna-directed dna polymerase | Rt | Transferase | Transferase-dna complex

Template:STRUCTURE 3klh

Crystal structure of AZT-Resistant HIV-1 Reverse Transcriptase crosslinked to post-translocation AZTMP-Terminated DNA (COMPLEX P)

Template:ABSTRACT PUBMED 20852643

About this Structure

3klh is a 6 chain structure of AZT-resistant HIV-1 reverse transcriptase, Monoclonal Antibody and Reverse transcriptase with sequence from Human immunodeficiency virus 1 and Mus musculus. Full crystallographic information is available from OCA.

See Also

• AZT-resistant HIV-1 reverse transcriptase
• Monoclonal Antibody
• Reverse transcriptase

Reference

• Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E. Structural basis of HIV-1 resistance to AZT by excision. Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. Epub 2010 Sep 19. PMID:20852643 doi:10.1038/nsmb.1908