1tqf

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spinqualitylabelsall models PDB ID 1tqf Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1tqf, resolution 1.80Å ()
Ligands:
Gene:	BACE1, BACE (Homo sapiens)
Activity:	Memapsin 2, with EC number 3.4.23.46
Structural annotation: Resources: CATH : 1Tqfa01, 1Tqfa02 InterPro : Ipr009120, Ipr009119, Ipr001461, Ipr009007, Ipr001969 Pfam : PF00026 UniProt : P56817
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of human Beta secretase complexed with inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of human Beta secretase complexed with inhibitor

Template:ABSTRACT PUBMED 15566281

About this Structure

1tqf is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T. Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases. J Med Chem. 2004 Dec 2;47(25):6117-9. PMID:15566281 doi:10.1021/jm049388p