1ej6

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Image:1ej6.gif

1ej6, resolution 3.6Å

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Reovirus core

Overview

The reovirus core is an assembly with a relative molecular mass of 52 million that synthesizes, modifies and exports viral messenger RNA. Analysis of its structure by X-ray crystallography shows that there are alternative, specific and completely non-equivalent contacts made by several surfaces of two of its proteins; that the RNA capping and export apparatus is a hollow cylinder, which probably sequesters its substrate to ensure completion of the capping reactions; that the genomic double-stranded RNA is coiled into concentric layers within the particle; and that there is a protein shell that appears to be common to all groups of double-stranded RNA viruses.

About this Structure

1EJ6 is a Protein complex structure of sequences from Reovirus sp. with as ligand. Full crystallographic information is available from OCA.

Reference

Structure of the reovirus core at 3.6 A resolution., Reinisch KM, Nibert ML, Harrison SC, Nature. 2000 Apr 27;404(6781):960-7. PMID:10801118

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