1exz
From Proteopedia
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STRUCTURE OF STEM CELL FACTOR
Contents |
Overview
Stem cell factor (SCF) plays important roles in hematopoiesis and the survival, proliferation, and differentiation of mast cells, melanocytes, and germ cells. SCF mediates its biological effects by binding to and activating a receptor tyrosine kinase designated c-kit or SCF receptor. In this report we describe the 2.3-A crystal structure of the functional core of recombinant human SCF. SCF is a noncovalent homodimer composed of two slightly wedged protomers. Each SCF protomer exhibits an antiparallel four-helix bundle fold. Dimerization is mediated by extensive polar and nonpolar interactions between the two protomers with a large buried surface area. Finally, we have identified a hydrophobic crevice and a charged region at the tail of each protomer that functions as a potential receptor-binding site. On the basis of these observations, a model for SCF small middle dotc-kit complex formation and dimerization is proposed.
Disease
Known diseases associated with this structure: Skin/hair/eye pigmentation 7, blond/brown hair OMIM:[184745]
About this Structure
1EXZ is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation., Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong XP, Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7732-7. PMID:10884405
Page seeded by OCA on Thu Feb 21 12:32:41 2008
Categories: Homo sapiens | Single protein | Joachimiak, A. | Kong, X. | Schlessinger, J. | Zhang, R. | Zhang, Z. | CA | SM | TRS | Scf
