1fcg
From Proteopedia
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ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA
Contents |
Overview
Fc gamma receptors bind IgG to initiate cellular responses against pathogens and soluble antigens. We have determined the three-dimensional structure of the extracellular portion of human Fc gammaRIIa to 2.0 A resolution providing a structural basis for the unique functions of the leukocyte FcR family. The receptor is composed of two immunoglobulin domains and arranged to expose the ligand-binding site at one end of domain 2. Using alanine mutants we find that the binding sites for IgG1 and 2 are similar but the relative importance of specific regions on the receptor varies. In crystals, Fc gammaRIIa molecules associate to resemble V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could cooperate to bind IgG in an asymmetric manner.
Disease
Known diseases associated with this structure: Lupus nephritis, susceptibility to OMIM:[146790], Malaria, resistance to OMIM:[604590], Systemic lupus erythematosus, susceptibility to OMIM:[604590]
About this Structure
1FCG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa., Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM, Nat Struct Biol. 1999 May;6(5):437-42. PMID:10331870
Page seeded by OCA on Thu Feb 21 12:37:15 2008
