1fmq

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Image:1fmq.gif

1fmq, resolution 2.Å

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Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG

Overview

2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.

About this Structure

1FMQ is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.

Reference

DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631

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