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1fml
From Proteopedia
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CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP
Overview
We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.
About this Structure
1FML is a Single protein structure of sequence from Spodoptera frugiperda with , and as ligands. Full crystallographic information is available from OCA.
Reference
A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:11323722
Page seeded by OCA on Thu Feb 21 12:40:16 2008
Categories: Single protein | Spodoptera frugiperda | Buck, J. | Kobayashi, M. | Newcomer, M E. | Pakhomova, S. | A3P | CA | RTL | 5'-diphosphate | Adenosine 3' | Dehydratase | Retinol | Sulfotransferase
