1lqb

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spinqualitylabelsall models PDB ID 1lqb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1lqb, resolution 2.00Å ()
Ligands:
Non-Standard Residues:
Structural annotation: Resources: CATH : 1Lqba00, 1Lqbb00, 1Lqbc01, 1Lqbc02 InterPro : Ipr000626, Ipr001232, Ipr011333, Ipr002714, Ipr011598, Ipr013655, Ipr000014, Ipr000700, Ipr001610, Ipr001321, Ipr014887, Ipr001092 Pfam : PF03931, PF01847 SCOP : d1lqba_, d1lqbb_, d1lqbc_ UniProt : Q15370, Q15369, P40337, Q16665
Functional annotation: Cellular component: nucleus cytoplasm membrane cytosol mitochondrion endoplasmic reticulum Biological process: protein complex assembly regulation of transcription, DNA-dependent transcription ubiquitin cycle RNA elongation from RNA polymerase II promoter protein modification process regulation of transcription from RNA polymerase II promoter cell cycle anti-apoptosis negative regulation of cell proliferation positive regulation of cell differentiation protein ubiquitination negative regulation of transcription from RNA polymerase II promoter cell morphogenesis response to stress negative regulation of cell cycle proteolysis protein stabilization homeostatic process signal transduction response to hypoxia transcription, DNA-dependent positive regulation of transcription regulation of transcription Molecular function: protein binding transcription elongation regulator activity transcription factor binding signal transducer activity transcription regulator activity histone acetyltransferase binding DNA binding RNA polymerase II transcription factor activity, enhancer binding transcription factor activity protein heterodimerization activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex 2 About this Structure 3 See Also 4 Reference

Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex

Template:ABSTRACT PUBMED 12050673

About this Structure

1lqb is a 4 chain structure of Factor inhibiting HIF with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Factor inhibiting HIF

Reference

• Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature. 2002 Jun 27;417(6892):975-8. Epub 2002 Jun 5. PMID:12050673 doi:http://dx.doi.org/10.1038/nature00767