3t3p

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3t3p

Contents 1 A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS 2 About this Structure 3 See Also 4 Reference

A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS

Template:ABSTRACT PUBMED 22422993

About this Structure

3t3p is a 8 chain structure of Monoclonal Antibody with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

See Also

• Monoclonal Antibody

Reference

• Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS. Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS. Sci Transl Med. 2012 Mar 14;4(125):125ra32. PMID:22422993 doi:10.1126/scitranslmed.3003576