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3arn

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Image:3arn.png

Template:STRUCTURE 3arn

Contents

Human dUTPase in complex with novel uracil derivative

Template:ABSTRACT PUBMED 22339362

About this Structure

3arn is a 3 chain structure of Deoxyuridine 5'-triphosphate nucleotidohydrolase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Miyahara S, Miyakoshi H, Yokogawa T, Chong KT, Taguchi J, Muto T, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Nomura M, Nagasawa H, Shuto S, Fukuoka M. Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors. J Med Chem. 2012 Apr 12;55(7):2970-80. Epub 2012 Mar 26. PMID:22339362 doi:10.1021/jm201628y

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OCA

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