This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1fkn
From Proteopedia
| |||||||||
| 1fkn, resolution 1.90Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-Standard Residues: | |||||||||
| Activity: | Memapsin 2, with EC number 3.4.23.46 | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Structure of Beta-Secretase Complexed with Inhibitor
Template:ABSTRACT PUBMED 11021803
About this Structure
1fkn is a 4 chain structure of Beta secretase with sequence from Homo sapiens. The July 2006 RCSB PDB Molecule of the Month feature on Amyloid-beta Precursor Protein by David S. Goodsell is 10.2210/rcsb_pdb/mom_2006_7. The July 2009 RCSB PDB Molecule of the Month feature on beta-Secretase by David Goodsell is 10.2210/rcsb_pdb/mom_2009_7. Full crystallographic information is available from OCA.
See Also
Reference
- Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science. 2000 Oct 6;290(5489):150-3. PMID:11021803
Categories: Amyloid-beta Precursor Protein | Homo sapiens | Memapsin 2 | RCSB PDB Molecule of the Month | Beta-Secretase | Ghosh, A. | Hong, L. | Koelsch, G. | Lin, X. | Tang, J. | Terzyan, S. | Wu, S. | Zhang, X C. | Alzheimer's disease | Aspartic protease | Base | Beta-secretase | Hydrolase-hydrolase inhibitor complex

