1hrn

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spinqualitylabelsall models 1hrn, resolution 1.8Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The crystal structures of recombinant glycosylated human renin in complex with several polyhydroxymonoamide inhibitors have been determined at up to 1.8 A resolution. The high resolution structures permit a detailed analysis of the conformation of renin, the interactions between the inhibitors and renin, and the network of ordered water molecules. The polyhydroxymonoamide inhibitors are bound with their backbones in an extended conformation, and with their side-chains occupying the S3 to S1 pockets. The inhibited renin molecules are shown to exist in both the closed and the open conformations. Inhibitors bound to the two distinct forms of renin can assume different conformations at the P3 position.

Disease

Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]

About this Structure

1HRN is a Single protein structure of sequence from Homo sapiens with , , and as ligands. The following page contains interesting information on the relation of 1HRN with [Pepsin]. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors., Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G, J Mol Biol. 1995 Jul 7;250(2):211-22. PMID:7608971

Page seeded by OCA on Thu Feb 21 13:04:10 2008