Sphingomyelinase

From Proteopedia

spinqualitylabelsall models PDB ID 2dds Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Sphingomyelinase complex with cobalt ion 2dds
Ligands:
Activity:	Sphingomyelin phosphodiesterase, with EC number 3.1.4.12
Related:	2ddr, 2ddt
Structural annotation: Resources: InterPro : Ipr005135 Pfam : PF03372 UniProt : P11889
Functional annotation: Biological process: cytolysis hemolysis by symbiont of host red blood cells Molecular function: sphingomyelin phosphodiesterase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates:	save as pdb, mmCIF, xml

Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide. The SMase is classified into 5 types according to their pH dependence and cation dependence.

3D structures of sphingomyelinase

3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
1xx1, 2f9r – SMase I – Loxosceles laeta
1zwx – SMase C – Listeria ivanovii
2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
2uyr – BcSMase (mutant)