1w50

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spinqualitylabelsall models PDB ID 1w50 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1w50, resolution 1.75Å ()
Ligands:
Activity:	Memapsin 2, with EC number 3.4.23.46
Related:	1fkn, 1m4h, 1py1, 1sgz, 1ujj, 1ujk, 1w51
Structural annotation: Resources: CATH : 1W50A01, 1W50A02 InterPro : Ipr001969, Ipr001461, Ipr009007, Ipr009120, Ipr009119 Pfam : PF00026 SCOP : d1w50a_ UniProt : P56817
Functional annotation: Cellular component: Golgi apparatus endosome integral to membrane integral to plasma membrane membrane Biological process: proteolysis beta-amyloid metabolic process membrane protein ectodomain proteolysis Molecular function: aspartic-type signal peptidase activity aspartic-type endopeptidase activity pepsin A activity peptidase activity beta-aspartyl-peptidase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 APO STRUCTURE OF BACE (BETA SECRETASE) 2 About this Structure 3 See Also 4 Reference

APO STRUCTURE OF BACE (BETA SECRETASE)

Template:ABSTRACT PUBMED 15451669

About this Structure

1w50 is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase
• Journal:Acta Cryst D:1

Reference

• Patel S, Vuillard L, Cleasby A, Murray CW, Yon J. Apo and inhibitor complex structures of BACE (beta-secretase). J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669 doi:10.1016/j.jmb.2004.08.018
• Xu Y, Li MJ, Greenblatt H, Chen W, Paz A, Dym O, Peleg Y, Chen T, Shen X, He J, Jiang H, Silman I, Sussman JL. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations. Acta Crystallogr D Biol Crystallogr. 2012 Jan;68(Pt 1):13-25. Epub 2011 Dec 9. PMID:22194329 doi:10.1107/S0907444911047251