4gev

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Image:4gev.jpg

Template:STRUCTURE 4gev

E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog

Template:ABSTRACT PUBMED 16768437

About this Structure

4gev is a 2 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 2g8m. Full crystallographic information is available from OCA.

Reference

  • Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28. PMID:16768437 doi:10.1021/bi060152s

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