Nuclear receptor

From Proteopedia

As exposed in the nuclear receptors facts book ^[1]

Structure

DBD (DNA Binding Domain)

LBD (Ligand Binding Domain)

spinqualitylabelsall models Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry 1ie8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image The structure of the LBD is strongly conserved throughout the familly of nuclear receptors. It is completely folded and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.

1. ↑ Vincent Laudet, Hinrich Gronemeyer, "The nuclear receptor factsbook", Publisher Academic Press, 2002, ISBN 0124377351, 9780124377356