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V-ATPase

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1 Your Heading Here (maybe something like 'Structure')
2 Introduction
3 V-ATPase components
4 Mechanism of rotation
5 V-ATPase structures
- 5.1 PDB
- 5.2 EMDB
6 References

Your Heading Here (maybe something like 'Structure')

Fitted structure of Thermus thermophilus V-ATPase, based on the EMD-5335 (PDB entry 3j0j)

Drag the structure with the mouse to rotate

Introduction

V-ATPase are mainly found in vacuoles of eukaryotic cells where they catalyze the hydrolyzation of ATP in order to transport solutes.

V-ATPase components

The structure of the whole V-ATPase complex can be divided in two domains. The V1 domain, which consist of eight different sub-units (A-H) and is responsible for the hydrolyzation of ATP, and the intermembrane V0 domain consisting of six different sub-units (a-f) and which transports the protons.