2j8h

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spinqualitylabelsall models 2j8h, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN

Overview

Most of the structure of the giant muscle protein titin is formed by small, modular domains. Many of them are predicted to be arranged in repeats with, short linkers that may be key determinants of the peculiar elastic, properties of titin. Here, we present the molecular structure of a tandem, arrangement of two immunoglobulin-like domains, A168 and A169, located, within the A-band segment of titin. The two domains are connected by a 17, residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational, flexibility of tandem domain motifs in titin. An unusual bulge within the, second domain, A169, is directly involved into binding to a sarcomeric, ligand, MURF-1, thus suggesting a dual role of this tandem ... [(full description)]

About this Structure

2J8H is a [Single protein] structure of sequence from [Homo sapiens] with GOL as [ligand]. Active as [Non-specific serine/threonine protein kinase], with EC number [2.7.11.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Rigid Conformation of an Immunoglobulin Domain Tandem Repeat in the A-band of the Elastic Muscle Protein Titin., Muller S, Lange S, Gautel M, Wilmanns M, J Mol Biol. 2007 Aug 10;371(2):469-80. Epub 2007 May 25. PMID:17574571

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