2j83

From Proteopedia

ULILYSIN METALLOPROTEASE IN COMPLEX WITH BATIMASTAT.

Overview

Human pappalysin-1 is a multi-domain metalloprotease engaged in the, homeostasis of insulin-like growth factors and the founding member of the, pappalysin family within the metzincin clan of metalloproteases. We have, recently identified an archaeal relative, ulilysin, encompassing only the, protease domain. It is a 262-residue active protease with a novel 3D, structure with two subdomains separated by an active-site cleft. Despite, negligible overall sequence similarity, noticeable similarity is found, with other metzincin prototypes, adamalysins/ADAMs and matrix, metalloproteinases. Ulilysin has been crystallised in a product complex, with an arginine-valine dipeptide occupying the active-site S(1') and, S(2') positions and in a complex with the broad-spectrum hydroxamic, acid-based ... [(full description)]

About this Structure

2J83 is a [Single protein] structure of sequence from [Methanosarcina acetivorans] with CA, ZN, BAT and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex., Garcia-Castellanos R, Tallant C, Marrero A, Sola M, Baumann U, Gomis-Ruth FX, Arch Biochem Biophys. 2007 Jan 1;457(1):57-72. Epub 2006 Oct 24. PMID:17097044

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