User:Eric Martz/Introduction to Structural Bioinformatics I
From Proteopedia
How to find, visualize, and understand 3D protein molecular structures
by Eric Martz, October 2 and 4, 2012
for Prof. Steven Sandler's course Microbiology 565: Laboratory in Molecular Genetics
University of Massachusetts, Amherst MA USA
Protein Structure
- 1. Amino acid sequence + protein chain conformation = protein function.
- A. Conformation can be a stable fold or intrinsically unstructured. Both commonly exist in the same protein molecule.
- B. Conformation is determined by sequence.
- Folded domains fold spontaneously (Anfinson, 1960's[1]), or with the help of chaperonins.
- The denaturation (unfolding) of a folded domain destroys its function.
Notes and References
- ↑ For a brief overview of Anfinson's protein folding experiments in the 1960's, see the first paragraph at Intrinsically Disordered Protein.
