Sandbox 34
From Proteopedia
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Introduction
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The is an awesome protein The Adenylate Kinase is made up of Adenylate Kinase also contains that help to hold the helices and sheets together. The also play a huge role in holding this protein together. However, the hydrophobic interactions are not the only thing holding it together or helping to keep its conformation. There are also many that help maintain the hydrophobic interactions and help stabilize the protein by interacting with one another. The interaction between the polar groups and the hydrophobic groups can be seen by the pink transparent hydrophobic groups and the green polar groups.
Proteins can be crystallized which can be very helpful for understanding the relative shape and sometimes functions of the protein. When proteins are crystallized they often have water molecules embedded in them because of how tightly and deep the water molecules can become wedged in the protein. The with the protein can be seen surrounding and inside some parts of the protein. The parts of the protein act differently with the water molecules. As seen in the previous link, the hydrophilic parts interact with the water molecules while the hydrophobic parts of the adenylate kinase stay away. Another view shows it transparently to better see the interactions.
Ligands on proteins vary greatly. The of adenylate kinase are based on the non-hydrolysable ligand of the protein. The residues interacting with the ligand are polar and charged because this ligand is also polar and charged, it is therefore stabilized by the residues. Also the are also interacting with the ligand.
