1l2c

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Image:1l2c.gif

1l2c, resolution 2.2Å

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MutM (Fpg)-DNA Estranged Thymine Mismatch Recognition Complex

Overview

MutM is a bacterial 8-oxoguanine glycosylase responsible for initiating base-excision repair of oxidized guanine residues in DNA. Here we report five different crystal structures of MutM-DNA complexes that represent different steps of the repair reaction cascade catalyzed by the protein and also differ in the identity of the base opposite the lesion (the 'estranged' base). These structures reveal that the MutM active site performs the multiple steps of base-excision and 3' and 5' nicking with minimal rearrangement of the DNA backbone.

About this Structure

1L2C is a Protein complex structure of sequences from Geobacillus stearothermophilus with as ligand. Full crystallographic information is available from OCA.

Reference

Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM., Fromme JC, Verdine GL, Nat Struct Biol. 2002 Jul;9(7):544-52. PMID:12055620

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