2zc9

From Proteopedia

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Template:STRUCTURE 2zc9

Contents 1 Thrombin in complex with Inhibitor 2 About this Structure 3 See Also 4 Reference

Thrombin in complex with Inhibitor

Template:ABSTRACT PUBMED 19520086

About this Structure

2zc9 is a 3 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hirudin
• Thrombin

Reference

• Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J Mol Biol. 2009 Aug 21;391(3):552-64. Epub 2009 Jun 9. PMID:19520086 doi:10.1016/j.jmb.2009.06.016
• Baum B, Mohamed M, Zayed M, Gerlach C, Heine A, Hangauer D, Klebe G. More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the s1 pocket of thrombin. J Mol Biol. 2009 Jul 3;390(1):56-69. Epub 2009 May 3. PMID:19409395 doi:10.1016/j.jmb.2009.04.051