2wcx
From Proteopedia
Contents |
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE IN COMPLEX WITH THIENOPYRROLE-BASED FINGER-LOOP INHIBITORS
Template:ABSTRACT PUBMED 19672916
About this Structure
2wcx is a 1 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Martin Hernando JI, Ontoria JM, Malancona S, Attenni B, Fiore F, Bonelli F, Koch U, Di Marco S, Colarusso S, Ponzi S, Gennari N, Vignetti SE, Rico Ferreira MD, Habermann J, Rowley M, Narjes F. Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase. ChemMedChem. 2009 Aug 11. PMID:19672916 doi:10.1002/cmdc.200900184
- Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfi A. Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site. J Biol Chem. 2005 Aug 19;280(33):29765-70. Epub 2005 Jun 13. PMID:15955819 doi:http://dx.doi.org/10.1074/jbc.M505423200
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Marco, S Di. | Allosteric inhibitor | Atp-binding | Envelope protein | Genotype 1b | Hcv | Helicase | Hydrolase | Membrane | Nni | Non nucleoside inhibitor | Ns5b | Nucleotide-binding | Polymerase | Rna replication | Rna-binding | Rna-dependent rna-polymerase | Transmembrane | Viral protein
