1m11
From Proteopedia
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structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy
Contents |
Overview
Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding regions are located close to the icosahedral twofold axes, in contrast to other enterovirus complexes where the viral canyon is the receptor binding site. This novel receptor binding position suggests that DAF is important for the attachment of viral particles to host cells, but probably not for initiating viral uncoating, as is the case with canyon-binding receptors. Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
1M11 is a Protein complex structure of sequences from Homo sapiens and Human echovirus 6. Full crystallographic information is available from OCA.
Reference
Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex., He Y, Lin F, Chipman PR, Bator CM, Baker TS, Shoham M, Kuhn RJ, Medof ME, Rossmann MG, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10325-9. Epub 2002 Jul 15. PMID:12119400
Page seeded by OCA on Thu Feb 21 13:50:20 2008
