3gzn

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Template:STRUCTURE 3gzn

Contents 1 Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 2 About this Structure 3 See Also 4 Reference

Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924

Template:ABSTRACT PUBMED 20129059

About this Structure

3gzn is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• NEDD8

Reference

• Brownell JE, Sintchak MD, Gavin JM, Liao H, Bruzzese FJ, Bump NJ, Soucy TA, Milhollen MA, Yang X, Burkhardt AL, Ma J, Loke HK, Lingaraj T, Wu D, Hamman KB, Spelman JJ, Cullis CA, Langston SP, Vyskocil S, Sells TB, Mallender WD, Visiers I, Li P, Claiborne CF, Rolfe M, Bolen JB, Dick LR. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol Cell. 2010 Jan 15;37(1):102-11. PMID:20129059 doi:10.1016/j.molcel.2009.12.024