2gc8

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Template:STRUCTURE 2gc8

Contents 1 Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase 2 About this Structure 3 See Also 4 Reference

Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

Template:ABSTRACT PUBMED 16722622

About this Structure

2gc8 is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

• RNA polymerase

Reference

• Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:16722622 doi:10.1021/jm060168g