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1p9t

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

Image:1p9t.png

Template:STRUCTURE 1p9t

CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS

Template:ABSTRACT PUBMED 12746549

Reference

Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003 Jun 13;300(5626):1763-7. Epub 2003 May 13. PMID:12746549 doi:10.1126/science.1085658
Pang YP. Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: catalytic efficiency regulated by substrate binding. Proteins. 2004 Dec 1;57(4):747-57. PMID:15690493 doi:10.1002/prot.20249