Calcineurin
From Proteopedia
Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. It contains a calmodulin-binding catalytic subunit and a Ca+2-binding regulatory subunit. There are 2 metal ions in CN active site. CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine. For more details see Group:MUZIC:Calcineurin.
3D structures of calcineurin
1tco – CN + FK-506-binding protein + Ca + Fe + Zn – bovine
1aui - hCN + Ca + Fe + Zn – human
1m63, 1mf8 - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn
2p6b - hCN + PVIVIT peptide + Ca + Fe + Zn
3ll8 - hCN + AKAP79 peptide + Ca + Fe + Zn
2jog - hCN catalytic subunit + NFAT peptide
2jzi - hCN catalytic subunit + calmodulin + Ca
2w73 - hCN calmodulin-binding domain + calmodulin + Ca
