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Factor inhibiting HIF
From Proteopedia
For details on Factor inhibiting HIF see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.
Contents |
3D Structures of factor inhibiting HIF
Update June 2012
1mze, 1h2n, 1iz3 – hFIH1α – human
FIH1α complex with small molecule
1yci, 3od4, 2yc0, 2yde– hFIH1α + inhibitor
2w0x - hFIH1α + pyridine derivative
2cgn – hFIH1α + succinate
2cgo – hFIH1α + fumarate
1mzf, 2wa3, 2wa4, 2yc0, 2yde – hFIH1α + oxoglutarate derivative
3kcx, 3kcy, 3od4 - hFIH1α + quinol derivative
FIH1α complex with polypeptide
1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
2ilm, 3d8c - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
3p3n, 3p3p - hFIH1α + Notch 1 peptide
2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
2y0i - hFIH1α + tankyrase 2 peptide
3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
FIH2α
2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
FIH1β
2b02, 1x0o - hFIH 1β PAS domain
2hv1, 2k7s - hFIH 1β PAS domain - NMR
