Interleukin receptor
From Proteopedia
Template:STRUCTURE 2b5i Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to typew I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).
3D structures of interleukin receptor
Interleukin receptor type I
Interleukin-2 receptor
1z92 – hIL2R α subunit + interleukin-2
2b5i - hIL2R α+β+γ subunits + interleukin-2
2erj - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)
3iu3, 3nfp - hIL2R α subunit + antibody
Interleukin-4 receptor
1iar - hIL4R α (mutant) subunit + interleukin-4
3bpl - hIL4R α + γ subunits + interleukin-4
3bpn - hIL4R α subunit + hIL13R α subunit + interleukin-4
3bpo - hIL4R α subunit + hIL13R α subunit + interleukin-13
Interleukin-5 receptor
3qt2 – hIL5R α (mutant) subunit + interleukin-5
Interleukin-6 receptor or gp130
1i1r – hIL6R β subunit + interleukin-6 homolog
1pvh - hIL6R β subunit + leukemia inhILbitory factor
2hmh - I6R β subunit + suppressor of cytokine signaling 3 – mouse
3l5i, 3l5j, 3l5h - hIL6R β subunit
1n26 - hIL6R α subunit
2arw - hIL6R α subunit - NMR
1p9m - hIL6R α + β subunits + interleukin-6
Interleukin-7 receptor
3up1 - hIL7R α subunit
3di2, 3di3 – hIL7R α (mutant) subunit + interleukin-7 (mutant)
Interleukin-13 receptor
3lb6 - hIL13R α2 (mutant) subunit + interleukin-13
Interleukin-15 receptor
2ers - hIL15R α subunit sushIL domain – NMR
2z3q, 2z3r, 2psm - hIL15R α subunit + interleukin-15
Interleukin-17 receptor
3jvf - hIL17RA extracellular domain + interleukin-17F
Interleukin-21 receptor
3tgx – hIL21R extracellular domain (mutant) + interleukin-21
Interleukin receptor type II
Interleukin-10 receptor
1j7v – hIL10R α (mutant) subunit + interleukin-10
1lqs, 1y6m, 1y6n - hIL10R α (mutant) subunit + interleukin-10 homolog
1y6k - hIL10R α (mutant) subunit + interleukin-10
3lqm - hIL10R β (mutant) subunit
Interleukin-22 receptor
3dgc – hIL22R α (mutant) subunit + interleukin-22
3dlq - hIL22R α (mutant) subunit + interleukin-2 (mutant)
Interleukin receptor of immunoglobulin family
Interleukin-1 receptor
1itb – hI1R1 extracellular domain + interleukin-1 β – human
1ira- hI1R1 extracellular domain + I1R1A
1g0y - hI1R1 extracellular domain + I1R1A peptide
3o4o - hI1R2 + interleukin-1 β
