Myosin light chain kinase

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Template:STRUCTURE 2x4f

Myosin light chain kinase (MLCK) phosphorylates the regulatory light chain of myosin at serine residue 19. This phosphorylation enables the myosin crossbridge to bind to the actin filament and allow muscle contraction to begin. Dephosphorylation of the myosin light chain stops muscle contraction.

3D structures of MLCK

2cqv – hMLCK 8th Ig-like domain – human – NMR
2yr3 - hMLCK 4th Ig-like domain – NMR
2x4f – hMLCK residues 40-388

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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