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spinqualitylabelsall models PDB ID 1cdw Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1cdw, resolution 1.90Å ()
Structural annotation: Resources: CATH : 1Cdwa02, 1Cdwa01 InterPro : Ipr012295, Ipr012294, Ipr000814 Pfam : PF00352 SCOP : d1cdwa1, d1cdwa2 UniProt : P20226
Functional annotation: Cellular component: nucleus transcription factor TFIID complex Biological process: transcription initiation from RNA polymerase II promoter transcription cell death transcription from RNA polymerase II promoter regulation of transcription, DNA-dependent Molecular function: general RNA polymerase II transcription factor activity binding DNA binding protein binding RNA polymerase II transcription factor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA 2 About this Structure 3 See Also 4 Reference

HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA

The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.

About this Structure

1cdw is a 3 chain structure with sequence from Homo sapiens. The July 2005 RCSB PDB Molecule of the Month feature on TATA-Binding Protein by David S. Goodsell is 10.2210/rcsb_pdb/mom_2005_7. Full crystallographic information is available from OCA.

See Also

• TATA-Binding Protein

Reference

• Nikolov DB, Chen H, Halay ED, Hoffman A, Roeder RG, Burley SK. Crystal structure of a human TATA box-binding protein/TATA element complex. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4862-7. PMID:8643494
• Cokol M, Nair R, Rost B. Finding nuclear localization signals. EMBO Rep. 2000 Nov;1(5):411-5. PMID:11258480 doi:10.1093/embo-reports/kvd092
• Hicks JM, Hsu VL. The extended left-handed helix: a simple nucleic acid-binding motif. Proteins. 2004 May 1;55(2):330-8. PMID:15048824 doi:10.1002/prot.10630