Grb10 SH2 Domain

Introduction

Grb10 is a member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. ^[1]

Dimerization of the Grb10 SH2 Domain

The crystal structure of Grb10 SH2 domain was an important step to understand how this protein interacts with IGF1 receptors and although the SH2 domain functions as an independent segment, it forms a dimer in physiological environments.