Nitroreductase

From Proteopedia

Template:STRUCTURE 1f5v

Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO₂ group. The NO₂ group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.

3D structures of nitroreductase

1f5v , 1oo5 – EcNR – Escherichia coli
3bm1, 1ds7 – EcNR minimal
3bm2 – EcNR minimal -FMN
1nec, 1kqd – EclNR – Enterobacter cloacae
1ywq, 2i7h – NR – Bacillus cereus
2b67 – NR – Streptococcus pneumonia
3ek3, 3hoi – NR – Bacterioides fragilis
3g14 – NR – Clostridium novyi
3h4o, 3koq - NR – Clostridium difficile
3gr3 – NR – Bartonella henselae
3hzn – NR – Salmonella typhimurium
3k6h – NR – Agrobacterium tumefaciens
2wqf – NR – Lactococcus lactis
2wzv – MsNR – Mycobacterium smegmatis
3of4 – NR FMN/FAD – Idiomarina loihiensis
3n2s – NR – Bacillus subtilis
3pxv – NR – Desulfitobacterium hafniense
3qdl – NR – Helicobacter pylori
3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
3r5r, 3r5w – MtNR F420

Nitroreductase binary complex

1kqb – EclNR + benzoate
1kqc – EclNR + acetate
1ylr, 1ylu - EcNR + acetate
1icr, 1icu, 1icv – EcNR + nicotinic acid
1ooq – EcNR + dicoumarol
1oo6, 1oon, 1idt – EcNR + benzamide derivative
1yki – EcNR + antibiotic
2wzw - MsNR + NADPH